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A Comprehensive Approach to:Osteoporosis and its Future Management

A Comprehensive Approach to:Osteoporosis and its Future Management

Bagher Larijani, MD, FACE

Professor of Internal Medicine and Endocrinology

Director-General and Chief Scientific Officer

Endocrinology and Metabolism Research Institute

WHO Collaborating Center for Research and Management of Diabetes and Osteoporosis

Tehran University of Medical Sciences

Outline

  • Definition of osteoporosis
  • Osteoporosis burden and epidemiology
  • Importance of screening and early diagnosis
  • Currently available diagnosis techniques and their limitations
  • Potentials of bone turnover markers (BTM)
  • Proteomics, genomics, and osteoporosis
  • Microfluidic chips for point-of-care screening  of osteoporosis
  • Management of osteoporosis
  • Necessity for a personalized approach to osteoporosis
  • Conclusions

Definition of Osteoporosis

  • Osteoporosis is:
    • A systemic skeletal disease
    • Defined by low bone mass and structural damage to bone tissue
    • Leads to increased bone fragility and high fracture risk
    • Three most common sites for fragility fractures are the hip, spine and wrist